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Message | User | Date(yyyy-mm-dd) |
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Diaphragm vs Peristaltic pump | qbio | 2004-08-04 | Click here to register. |
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Hello,
Currently I'm using a peristaltic pump to wash .5um latex beads in a TFF system. SEM analysis shows that there is a small degree of damage induced during the process, presumably from the pump. Would switching to a diaphragm pump potentially remediate this problem or are pumps generally known to damage beads? | | |
| ppatel | 2004-08-09 | Click here to register. |
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 | Hi, my name is James Simmons (jsimmons@spectrumlabs.com) - I have significant latex experience at Spectrum Labs and your inquiry was forwarded to me. I do not often encountered complaints about fractured or damaged beads resulting from the peristaltic pump, although there a few researchers shun peristaltic pumps for this reason. All pumps compress the fluid in some way. The principal advantage of a peristaltic pump is that it does not require any contact between any pump parts and the sample, making cleaning and validation much easier. It also allows the fluid path to be preassembled and autoclaved independent of the pump. I am also not aware of damage caused by diaphragm pumps, but I believe the methodology used by diaphragm pumps is similar to peristaltic pumps from the point of view of the sample. Your problem may be a function of the fragility of the bead, and if so, changing pumps may not yield improved results. If you contact me directly at jsimmons@spectrumlabs.com, I would be happy to examine your application in greater detail.
I hope this is of some help to you. James Simmons |
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